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- #I doser version 4.5 (cracked) over 200 doses cracked#
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The objective of this study is to demonstrate that (1) proportionally similar strengths of ER tablets exhibiting similar in vitro dissolution profiles do not always assure BE and (2) different strengths that do not meet the criteria for dissolution profile similarity may still be bioequivalent. Current regulatory guidelines allow for biowaiver of proportionally similar lower strengths of an extended release (ER) product provided it exhibits similar dissolution to the higher strength in multimedia. Waiver of a BE study (biowaiver) is highly desired for such changes.
#I doser version 4.5 (cracked) over 200 doses how to#
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#I doser version 4.5 (cracked) over 200 doses cracked#
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